Currently the 486 is just a fancier looking 386 with slightly better pickups, but the 386 and 486 *used* to be pretty different platforms.
In addition to the pickup differences, the wood in the older 386 differs from the 486. Before Eastman switched to using maple laminate in the 386es they were using mahogany for the back and sides with rosewood for the fretboard. I'm not sure if the neck wood was maple or mahogany. These had a pretty big impact on the sound between the two models.
The 486 is essentially a clone of Gibson's 355, where the 386 is (or was) a clone of the 335.
In addition to the pickup differences, the wood in the older 386 differs from the 486. Before Eastman switched to using maple laminate in the 386es they were using mahogany for the back and sides with rosewood for the fretboard. I'm not sure if the neck wood was maple or mahogany. These had a pretty big impact on the sound between the two models.
The 486 is essentially a clone of Gibson's 355, where the 386 is (or was) a clone of the 335.